Grey’s Anatomy is one of the most popular TV shows of all time and it’s approaching season 20 on ABC.
Ellen Pompeo, the long-running star of the series, left the show in the middle of season 19.
Throughout the last two decades, there have been more than 20 series regular actors who have left the series after spending many years at Grey Sloan Memorial Hospital.
Head inside to see all of the series regular actors who have left Grey’s Anatomy…
Keep scrolling to see all of the series regular actors who have left Grey’s Anatomy…
Isaiah Washington
Character: Preston Burke
Seasons on Show: 3
Left After: Season 3
Kate Walsh
Character: Addison Montgomery
Seasons on Show: 2 as series regular
Left After: Season 3 (returned for guest appearances through season 8)
Brooke Smith
Character: Erica Hahn
Seasons on Show: 2 as series regular
Left After: Season 5
T. R. Knight
Character: George O’Malley
Seasons on Show: 5
Left After: Season 5 (later returned for a guest appearance)
Katherine Heigl
Character: Izzie Stevens
Seasons on Show: 6
Left After: Season 6
Chyler Leigh
Character: Lexie Grey
Seasons on Show: 5 as series regular
Left After: Season 8 (later returned for a guest appearance)
Eric Dane
Character: Mark Sloan
Seasons on Show: 7 as series regular
Left After: Season 9 (later returned for a guest appearance)
Sandra Oh
Character: Cristina Yang
Seasons on Show: 10
Left After: Season 10
Gaius Charles
Character: Shane Ross
Seasons on Show: 1 as series regular
Left After: Season 10
Tessa Ferrer
Character: Leah Murphy
Seasons on Show: 1 as series regular
Left After: Season 10 (returned as recurring in season 13)
Patrick Dempsey
Character: Derek Shepherd
Seasons on Show: 11
Left After: Season 11 (later returned for a guest appearance)
Sara Ramirez
Character: Callie Torres
Seasons on Show: 10 as series regular
Left After: Season 12
Jerrika Hinton
Character: Stephanie Edwards
Seasons on Show: 4 as series regular
Left After: Season 13
Martin Henderson
Character: Nathan Riggs
Seasons on Show: 3 as series regular
Left After: Season 14
Sarah Drew
Character: April Kepner
Seasons on Show: 8 as series regular
Left After: Season 14 (later returned for a guest appearance)
Justin Chambers
Character: Alex Karev
Seasons on Show: 16
Left After: Season 16
Giacomo Gianniotti
Character: Andrew DeLuca
Seasons on Show: 6 as series regular
Left After: Season 17
Jesse Williams
Character: Jackson Avery
Seasons on Show: 11 as series regular
Left After: Season 17 (returned for guest appearance in season 18)
Greg Germann
Character: Tom Koracick
Seasons on Show: 2 as series regular
Left After: Season 17 (later returned for a guest appearance)
Richard Flood
Character: Cormac Hayes
Seasons on Show: 2 as series regular
Left After: Season 18
Ellen Pompeo
Character: Meredith Grey
Seasons on Show: 19
Left After: Season 19
Scott Speedman
Character: Nick Marsh
Seasons on Show: 2
Left After: Season 19
Kelly McCreary
Character: Maggie Pierce
Seasons on Show: 10
Left After: Season 19